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As temozolomide is widely administered to patients with IDH1-mutant gliomas, Subramani and colleagues [116] used 1 H MRS and hyperpolarized 13 C MRS to identify increased Glu production as a potential metabolic biomarker of temozolomide response in genetically engineered and patient-derived models: in temozolomide-treated cells a significant increase in Glu and 13 C-Glu levels was observed

Only compounds observed in the Pool QC with an area 20% weight loss compared to control or age-matched mice)

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E.MeinhardtM.PagelR.SchampelA.et al (2021)

Endocrine Connections, 6 (8), 647658