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The three most effective (semaglutide, tirzepatide, retatrutide) are GLP-1 agonists: they mimic a natural gut hormone that tells your brain you are full

Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy

Besides, it upregulates the synthesis of many other peptide hormones

BioDrugs, 12(2), 139-157

However, nerve pain is more common to a B12 deficiency, while bone pain is typically associated with a lack of vitamin D
