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In addition to limited absorption via the IF, the intake of high-dose supplements leads to passive diffusion, i.e., the vitamin can freely enter the bloodstream without IF binding and receptor uptake

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Strengthening the muscles surrounding affected joints reduces mechanical load, improves stability, and enhances movement efficiency

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Normal B12 ranges typically fall between 200-900 pg/mL, though functional B12 status is better assessed by methylmalonic acid (MMA) and homocysteine levels

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DOI: 10.1210/jc.2011-0256 31

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