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Furthermore, compared to the control group, there was a decrease in the percentage of CD45, a marker of microglial activation, in the cortex (above 18%) and the hippocampus (28%)

Vitamin E modulates inflammation by interacting with cyclooxygenase (COX) enzymes, which are responsible for the synthesis of prostaglandins at the site of inflammation (Schubert et al

doi: 10.1139/h03-045 [DOI] [PubMed] [Google Scholar] [89].Cheng AJ, Jude B, Lanner JT

6.3 The kynurenine pathway: an interactive mechanism linking gut microbiota, immunity, and neurotransmitters Specific neurotransmitters, such as GABA, dopamine, glutamate, and serotonin (5-HT), are derived from precursors tyrosine and tryptophan, which are transported across the BBB into the CNS and subsequently converted into neurotransmitters (213)