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Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [12]
This mechanism is especially relevant in melasma, a common hyperpigmentation disorder where oxidative stress is thought to worsen pigmentation
doi: 10.3892/ijo.2014.2382 188 DennyCAHeineckeKAKimYPBaekRCLohKSButtersTDet al
Chronic pain and sleep disturbances: a pragmatic review of their relationships, comorbidities, and treatments
