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The FDA approved IDH inhibitors (Enasidenib and Ivosidenib) have shown very promising results by inducing differentiation and durable remission in the AML patients ( Owing to oncogenic signaling and abnormal growth, AML cells are known to have higher levels of oxidative stress from the reactive oxygen species (ROS) compared to non-malignant hematopoietic stem/progenitor cells

N., Hossain, M., Adnan, M., Rahaman, C

Consequently, any skin irritation with basement membrane disruption can deteriorate melasma condition and also induce persistence or recurrence type of the disease (Kwon et al., 2016)

Study BNT162-01 (Study 1) was a Phase 1/2, 2-part, dose-escalation trial that enrolled 60 participants, 18 through 55 years of age