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Research has also examined its role in upregulating matrix metalloproteinase (MMP) activity alongside their inhibitors (TIMPs), suggesting a finely balanced role in extracellular matrix remodelling rather than simple collagen deposition

PMID: 28120158

IGFBP-1 gene is transcriptionally regulated by insulin in the liver [169]

As dermatologists, we must emphasize the importance of healthy, well-cared-for skin, regardless of tone, and discourage treatments that reinforce negative stereotypes surrounding skin color