glutathione colon cancer DLAT sustains redox homeostasis and prevent colorectal from ferroptosis by regulating SLC25A39-mediated mitochondrial transport Glutathione Depletion and Stalwart Anticancer

10.2337/dc22-2494 163 WuH.EsteveE.TremaroliV.KhanM

As a powerful internal antioxidant, it works to neutralize free radicals and support skin brightening for a healthy, radiant glow

383 Moreover, we also found that bromodomain containing 4 (BRD4) is upregulated in ICB-resistant melanoma patients, and inhibiting BRD4/AKR1C2 axis by bromodomain and extra-terminal motif (BET) inhibitors has been shown to enhance the susceptibility of melanoma to ferroptosis and immunotherapy

[PubMed: 29563157] 109

After its synthesis, GSH is delivered to other intracellular compartments, including mitochondria, endoplasmic reticulum, nucleus, and to the extracellular space (e.g., blood plasma and bile) for utilization by other cells and tissues (Figure 1B)