drug causes cysteine starvation and glutathione depletion Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis Crosstalk between cystine and glutathione

[27] Ceasing glutamine supplementation in people adapted to very high consumption may initiate a withdrawal effect, raising the risk of health problems such as infections or impaired integrity of the intestine

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Therefore, this transport mechanism is not only important for ensuring accurate synaptic signaling but also for limiting the EAA-mediated excitotoxicity Figure 2

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