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2016;16:e37973
It sits at a key branch of sulfur amino acid metabolism and helps decide how homocysteine, cysteine, glutathione, and hydrogen sulfide are handled inside cells
314 Additionally, IDO1 inhibitors, such as epacadostat, target metabolic immunosuppression by blocking the conversion of tryptophan to kynurenine, a pathway that suppresses effector T cell activity while promoting regulatory T cell expansion
10.1016/j.apnr.2023.151745 79
