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The most common genetic mutation (permanent alteration in the DNA sequence) that produces Gilberts syndrome occurs in an area of DNA near the UGT1A1 gene, known as promoter region, which controls the production of the UGT enzyme

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[DOI] [PMC free article] [PubMed] [Google Scholar] [33].Ivanina AV, Nesmelova I, Leamy L, Sokolov EP, Sokolova IM (2016)

Since 1962, in order to bring a drug to market, manufacturers have been required to run controlled trials in human beings to gauge safety and effectiveness