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Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s11845-023-03602-4

Consumers taking unauthorized peptide drugs are exposed to a variety of risks, including, but not limited to, hormonal imbalance, mood swings, blood sugar imbalance, liver or kidney damage, blood clots, and growth of cancerous tumours

It is essential for many functions within the body and is vital for maintaining optimum health including

This has substantial implications for the development and implementation of policies and practices

Therefore, understanding what factors can negatively modulate tight junction permeability and how pharmacological approaches such as LA act to protect or restore the tight junction barrier before or after injury is critical for developing preventative or therapeutic approaches