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TREM2 also modulates APOE isoform-specific effects: TREM2 deficiency exacerbates microglial A clearance deficits in APOE 4 mice (274), supporting TREM2-targeted therapies for APOE 4-associated AD

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Altered oxidative metabolic responses in vitro of alveolar macrophages from asymptomatic cigarette smokers

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Alle zur Zeit bestehenden klassischen Therapien sttzen entweder das Phnomen der Oxidation, also die oxidative Seite lebender Systeme, oder greifen durch Arzneimittel, die als Xenobiotika zu ihrem Abbau und zur Metabolitbildung der Oxidation bedrfen, in die "Oxidative Potenz" des Stoffwechsels ein wie Cytochrom-p-450-System und Arzneimittelabbau.All currently existing classic therapies either support the phenomenon of oxidation, ie the oxidative side of living systems, or intervene in the "oxidative potency" of the metabolism like cytochrome by drugs that need xenobiotics to break them down and to produce metabolites