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Functional analysis of MTF-1 and MT promoters and their transcriptional response to zinc (Zn) and copper (Cu) in yellow catfish Pelteobagrus fulvidraco

Hypoxia-inducible factor 1 (HIF-1) is a transcription factor characterized by a basic helix-loop-helix/Per-Arnt-Sim domain, which plays a key role in regulating cellular responses to oxygen deprivation and acts as a crucial driver in tumor angiogenesis [8]

Bronzina E, Clement A, Marie B, Fook Chong KT, Faure P, Passeron T

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In addition to the nanoparticles being able to affect M2 TAMs in TME mentioned above, inhibition of lactate production can also effectively restore immunosuppressive TME based on the fact that cancer cells continue to produce lactate through aerobic glycolysis thereby promoting TAMs polarization to the M2 phenotype