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This article will review how to give an intramuscular (IM) injection in the deltoid muscle using the z-track technique

In addition to genetic testing, plasma folate and homocysteine levels can be measured to assess the impact of MTHFR gene mutations on folate metabolism

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So, it is now established that tolerance to respiratory depression is lower than the tolerance to analgesia (Mohammed et al., 2013) and might explain fatal overdoses (White and Irvine, 1999)