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In particular, negative results were reported with endostar, sunitinib, sorafenib, vandetanib, or thalidomide in combination with chemotherapy in the first-line setting, with sunitinib as maintenance therapy, with sunitinib, cediranib, and nintedanib as single agents or ziv-aflibercept in combination with topotecan in second-line setting

Meanwhile, a research team, composed of a 4th-year radiology resident (DW Kong), two 8th-year orthopedic resident (J Chen, XF Ma), and three 4th-year orthopedic residents (YL Sun, YP Lin, and MC Yin), graded all the IVD-degeneration levels independently according to the modified Pfirrmann grading system 10