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this is considered to be due to an imbalance between glutamate and gamma-aminobutyric acid (GABA) neurotransmission, together with dysregulation of glucocorticoids as a result of exposure to prolonged or traumatic stress

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In SLE, the generation and function of various subsets of T helper cells specifically Th1, Th2, Tregs, and Th17 cells are greatly compromised, which is the basis of the diseases complex immunopathology (115117)

The net effect of all these stimulant drug effects is to produce longer-lasting and more widespread activation of DA receptors, with subtle but important differences between the pure uptake blockers and amphetamines

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