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Most practitioners recommend starting at 250-300 mcg daily to assess tolerance, then potentially increasing to 400-500 mcg if initial response is suboptimal and no side effects occur

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MedlinePlus: B Vitamins NCBI: Statpearls: Vitamin B12 Deficiency (Cobalamin) Cochrane Database of Systematic Reviews: Progesterone or ProgestogenReleasing Intrauterine Systems for Heavy Menstrual Bleeding ScienceDirect: Medicine: Iron, Vitamin B12 and Folate Pernicious Anaemia Society: Symptoms of Pernicious Anaemia Journal of Human Nutrition and Dietetics: Avoidance of Meat and Poultry Decreases Intakes of Omega-3 Fatty Acids, Vitamin B12, Selenium and Zinc in Young Women EBSCO Publishing: Dysmenorrhea Medical News Today: Everything You Need to Know About Vitamin B-12 National Institutes of Health Office of Dietary Supplements: Vitamin B12 Penn State Hershey: Milton S

Hydroxocobalamin provides a longer-acting effect compared with oral B12 supplements, which reduces the frequency of dosing

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