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In both rats and humans administered APAP, the endogenous quantities of p -cresol sulfate in the urine were correlated with liver effects (rat)37 and the APAP-sulfate/APAP-glucuronide ratio (humans),38 directly leading to the concept of pharmacometabonomics.37,38 Similarly, urinary concentrations of p -cresol and p -cresol sulfate have been found to be elevated in children with autism39 and when the urinary APAP-sulfate/APAP-glucuronide ratio was determined for 20 low functioning autistic children receiving the drug it was found to be significantly lower than for the controls.40 The prediction of acute APAP-induced liver injury in humans, and consequent treatment needs or patient outcomes during hepatotoxicity remains difficult

10.1128/AEM.72.5.3646-3652.2006 Appl

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Anal Biochem 190:212219 Franco R, Panayiotidis MI, Cidlowski JA (2007) Glutathione depletion is necessary for apoptosis in lymphoid cells independent of reactive oxygen species formation

It is suggested that Gq protein activation induces PLC/PIP 2 hydrolysis and generates IP 3 and DAG, which stimulate TRPC and increase intracellular Ca 2+ in response to light stimulation (Contreras et al., 2021