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Description
First, they engineered different hIPSC lines with patient-derived germline NF1 mutations and with KIAA1549-BRAF fusion, then they differentiated these hIPSCs to multipotent human neural stem cells capable of generating both neuronal and glial lineage cells (hINPCs)

These labs allow detection of pre-existing contraindications (impaired kidney or liver function, subclinical thyroid dysfunction) and provide reference values for interval monitoring during the protocol

AIMS Microbiol

Heme synthesis begins and ends in the mitochondrion, with part of it occurring in the cytoplasm

This timeframe balances practical portabilityallowing patients to travel or keep medications at their workplacewith safety margins that ensure the compound remains chemically stable
