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Yoneda et al

Additional advantages of the GEM-handle are the combination with simple site-specific labeling chemistry guaranteeing consistent label positioning and the interchangeability of the fluorophore, which stands in contrast to trivalent platforms that necessitate comprehensive redesign and synthesis for fluorophore substitution

Yang X, Yu D, Xue L, Li H, Du J

This heightens susceptibility to the toxic effects of iron overload, disrupting intestinal mucosal homeostasis and triggering local inflammation and cell death, ultimately precipitating the onset of gut-associated diseases ( Iron overload-related diseases rank among the most prevalent genetic disorders in humans, characterized pathologically by systemic iron accumulation resulting from excessive dietary iron absorption and iron-induced oxidative stress responses ( 3 Ferroptosis and inflammatory bowel disease The imbalance in ferroptosis regulation plays a key role in the pathogenesis of various diseases