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The limited efficacy of the currently approved clinical drugs underscores an urgent call for the study and development of new drugs and innovative therapies for ALS

10.1089/ars.2006.8.1865 [DOI] [PubMed] [Google Scholar] 31.Kemp M, Go Y-M, Jones DP

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By targeting the same or distinct biological pathways, these approaches can increase the pharmacodynamic effect while lowering the risk of drug resistance