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The sources and pathways associated with pathological Ca2+ homeostasis in glaucoma may include ion channels within the plasma membrane and calcium release from intracellular compartments such as the endoplasmic reticulum (ER), mitochondria and lysosomes

The GSH depletion was the earliest event in BSO plus HCH-induced signaling and the apoptotic effect of this combination was correlated with the enhanced depletion of GSH as glutathione precursor GME abrogated activation of JNK, ERK and the apoptosis

Hypermelanotic pigmentation is a typical sign of overt disease and is seen in more than 70% of patients

Rimessi A, Bonora M, Marchi S, Patergnani S, Marobbio CM, Lasorsa FM, et al

The pro-ferroptotic lipid 15-HpETE-PE that released by ferroptotic cancer cells will induces immune cells undergo ferroptosis in the TME (Kapralov et al., 2020)