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In AD, cerebrovascular dysfunction occurs earlier among E4 carriers (Veitch et al., 2019), which could lead to impairments in nutrient sensing and metabolite exchange between the brain and periphery, thereby negatively impacting brain bioenergetics by rendering brain areas of high energetic needs (e.g., the hippocampus) vulnerable to pathologies such as amyloid (Veitch et al., 2019

In this respect, CT2 can be regarded as a drug target for gastric cancer [33]

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Bonilla, Guerrero R., Wolfe, L

Alcoholic beverages provide empty calories and may stimulate appetite, while alcohol metabolism affects hepatic glucose regulation