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600 Despite the large number of studies on its potential, translating these effects into robust clinical outcomes has proven challenging
Wasmuth EV, Broeck AV, LaClair JR, Hoover EA, Lawrence KE, Paknejad N, et al

Animal models: To analyse the possible role of CBS in Down syndrome, there are several lines of transgenic mice expressing the human CBS gene described in Herault et al, Disease Models & Mechanisms 2017

PloS One 8 , e59154 (2013)

R., Gillen, A
