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Cannot tolerate GI side effects of GLP-1 agonists: Consider alternatives

Each receptor system contributes distinct metabolic effects and GLP-1 influencing insulin secretion and appetite, GIP influencing incretin response and fat cell biology, and glucagon driving energy expenditure and hepatic fat metabolism

For most patients with simple steatosis, lifestyle modifications form the cornerstone of treatment, with the goal of reducing liver fat content and preventing advancement to more severe forms of liver disease