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In contrast, males seem more susceptible in developed nations, which indicates a possible genetic and lifestyle role in development of the disease

Van Geest RJ, Klaassen I, Lesnik-Oberstein SY et al (2013) Vitreous TIMP-1 levels associate with neovascularization and TGF-2 levels but not with fibrosis in the clinical course of proliferative diabetic retinopathy

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Overall, RN provides neuroprotection against RGC loss via both routes, with oral delivery offering additional benefits in reducing disease severity (148)

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