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Patients with PSC have an increased risk of osteoporosis and might also be deficient in vitamin D and other fat-soluble vitamins

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Papo N, Seger D, Makovitzki A, Kalchenko V, Eshhar Z, Degani H, et al

These hormones play many important roles in the metabolism

hypotheses state that genetic predisposition, stressful life events, peripheral (inflammatory) and central (cognitiveemotional) mechanisms interplay to create pain dysperception owing to neuromorphological modifications (nociplastic pain)