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In addition, Irg1-deficient phagocytes, which cannot produce itaconate, have shown increased susceptibility to M.tb infection, with infected mice exhibiting higher bacterial loads, reduced survival, exacerbated inflammation, extensive necrotizing granuloma formation and elevated neutrophil infiltration in the lungs [104, 105]

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Maintenance Dosing Strategies For long-term health and anti-aging, some users transition to a maintenance protocol after a full cycle

JAMA, vol