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Front Aging Neurosci (2014) 6:177
2023 , 136 , jcs260746
But on a bigger scale, its about reducing the bacteria and inflammation that thrive in those tiny hidden spaces
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Altogether, despite their promise, 3D in vitro models face technical challenges, such as long culture times, high costs, batch-to-batch variability (notably in organoids) and mostly lack of vascularization, which restricts nutrient/oxygen delivery and causes necrosis in larger constructs
