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ER has less of a role in the classical estrogen target tissues and has been found to be more dominant in the brain, cardiovascular system and the colon [87, 88]

doi: 10.2147/DDDT.S79458 198 HunterDJBierma-ZeinstraS

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Patients with a severe needle phobia, tremors, poor eyesight, or cognitive impairment should have a partner, family member, or healthcare provider administer the injection instead

Thus, increased homocysteine levels (hyperhomocysteinemia), and increased methylmalonic acid (MMA) levels are symptoms of possible vitamin B 12 deficiency