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doi: 10.1177/0961203308089990
Brightening treatments help reverse the damage
1, thiol-mediated metabolism of DSF and RS-DDTC releases DDTC that can chelate divalent (e.g., Mg 2+ , Cu 2+ , Zn 2+ ) and trivalent (e.g., Fe 3+ ) metals in the cell
Boutant M, Kulkarni SS, Joffraud M et al (2017) Mfn2 is critical for brown adipose tissue thermogenic function
In those patients, addressing the underlying metabolic dysfunction first, through dietary intervention, GLP-1 therapy if indicated, or NAD+ support for cellular energy metabolism, is the clinical priority
