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Availability of data and materials The datasets supporting the conclusions of this article are included within the article

Pigment epithelium-derived factor (PEDF), the overexpression of which upregulated GPX4 and FTH1 that proved to suppress LPO and ferroptosis induced by NaIO 3 , was recently viewed as an upstream regulatory molecule of RPE ferroptosis (86)

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Induction of hyperphosphorylated tau in primary rat cortical neuron cultures mediated by oxidative stress and glycogen synthase kinase-3

Additionally, it protects the energy producing enzyme Glyceraldehyde 3-phosphate dehydrogenase from attack by nitric oxide.