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Acknowledgments and Funding: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This research was funded by the Ministry of Science and Technology (MOST 111-2314-B-418-004, MOST 111-2321-B-418-002-, NSTC 112-2321-B-418-004-, and NSTC 112-2314-B-418-010-MY3), Far Eastern Memorial Hospital (FEMH