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The system rapidly identified formulations that met multiple requirements (particle size, stability, drug loading, and release profile), thus accelerate the transition from screening to optimization [198]

PCa cells (such as LNCaP, C4-2B, PC-3, and DU-145 cell lines) treated with recombinant IGF-1 have an enhanced ability to degrade the underlying basement membrane and invade the ECM owing to EMT [46]

The diagnostic criteria for MASLD encompass hepatic steatosis and at least one of five cardiometabolic risk factors, of which hepatic steatosis, caused by an imbalance between lipid production and removal, is a defining feature of MASLD [2,4,5]

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