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(1977) Improvement of cis-dichlorodiammineplatinum (NSC-119875): Therapeutic index in an animal model

This modification regulates proteins involved in metabolism (glyceraldehyde-3-phosphate dehydrogenase, pyruvate kinase), signal transduction (protein kinases, phosphatases), transcription (NF-B, AP-1), cytoskeletal dynamics (actin), and apoptosis (caspases)