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A study investigating the effects of Tai Chi Chuan: individuals with traumatic brain injury compared to controls

To confirm their role in clinical research, we searched the Clinical Trial Database ( using the keyword "Intranasal Drug AND Mitochondria AND Brain Injury AND CNS Disease", which revealed zero results, confirming that none of these compounds have been tested clinically employing the intranasal route of drug delivery

Systemic iron metabolism is finely regulated through multiple mechanisms, including transcriptional, translational, post-translational (e.g., ubiquitin-proteasome-mediated protein degradation), and hormonal mechanisms [12]

Astrogliosis is prevalent in the epilepsies, and interestingly a mouse forebrain neuron-specific knockout of SOD2 resulted in seizures, oxidative stress, and marked GFAP and vimentin gene upregulation, indicative of astrogliosis resulting from increased neuronal mtROS (Mndez-Armenta et al., 2014

To further elucidate the catalytic mechanism and the difference in CAT-mimicking activity of Fe 1 /NC SAzymes, we carried out density functional theory (DFT) calculations