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ZO-1 stabilizes the tight junction solute barrier through coupling to the perijunctional cytoskeleton

In line with the IR-senescence data, low effective doses of FOXO4-DRI were well tolerated in normal IMR90 compared to ABT-737, while being very potent against Doxorubicin-senescent cells at higher doses (Fig

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This approach helps to smooth out the concentration curve, minimizing the dramatic peak after dosing and the deep trough before the next dose