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However, co-treatment with 1 M Dihexa and 10 M rapamycin showed significant attenuation of hair cell protection at 50 and 100 M neomycin

The stomach is a hostile environment by design
The dermal papilla contains fibroblasts, blood vessels, and signaling cells that regulate hair growth
The mechanism may involve modulation of key enzymes regulating triglyceride levels, such as FAO and fatty acid synthase (FAS) [155]

The Jarisch-Herxheimer reaction in leptospirosis: possible pathogenesis and review