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Nrf2 is involved in not only the regulation of GSH synthesis and reduction via upgrading some enzymes and proteins (SLC7A11, GCLM, GCLC, GR) but also the activation of GSH-dependent antioxidant enzymes (GPX, GST) [200, 201]

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4.1.3 -KGDH -Ketoglutarate dehydrogenase (-KGDH) catalyzes the generation of succinyl CoA, CO 2 and NADH from -ketoglutarate, NAD + and CoA