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10.1007/s11357-024-01176-2 Geroscience 136 MinokoshiY.AlquierT.FurukawaN.KimY

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The first step of glutathione synthesis involves the formation of glutamylcysteine from glutamate and cysteine in an ATP dependent reaction catalysed by glutamate-cysteine-ligase (GCL) which requires either Mg 2+ or Mn 2+ as a cofactor

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10.1038/nature13165 Nature 24 HawkinsR.DeJosephM

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