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Notably, the PDK inhibitor dichloroacetate (DCA) restores PDH activity and reduces lactate production in PASMCs [73]

Analysis shows that metformin modulates metabolism through AMPK activation across multiple tissues, though the precise mechanisms linking AMPK activation to improved insulin sensitivity remain an area of active investigation (331)

Massage therapy can also help reduce muscle spasms that contribute to prolonged nerve irritation, and is a useful complement to a structured treatment plan

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