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Gene activity scores were generated by quantifying unique molecular identifiers (UMIs) mapped to the gene coordinates and the 2 kb upstream region

However, since lactate is a metabolic byproduct and greater metabolic demand increases lactate production, the remaining muscle cells produce even more lactate than usual due to their increased workload, hastening the accumulation of lactate and exacerbating neuronal destruction and muscular atrophy

doi: 10.1515/jbcpp.2007.18.2.115 4 VonaRPallottaLCappellettiMSeveriCMatarreseP

Conversely, rare non-functioning mutations in ALPL cause a genetic condition called hypophosphatasia, which in addition to high levels of pyrophosphate, causes high levels of P5P.[ref] Peripheral Neuropathy and Vitamin B6: Vitamin B6 deficiency is one of the more common causes of peripheral neuropathy.[ref][ref] On the other hand, excess consumption of vitamin B6 supplements for longer periods (months to years) has caused neuropathy or movement disorders in a few individuals

YSZ and GC performed the research