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Description
Abstract Diabetic neuropathy (DN) is a prevalent and debilitating complication of diabetes, causing substantial morbidity and negatively impacting the quality of life for millions of individuals worldwide

Sano H, Kane SE, Sano E, Minea CP, Asara JM, Lane WAS, et al

Separation of NAD/NADH, NADP/NADPH and additional energy carriers was achieved by the following LC gradient scheme (Table S3) using mobile phase A (5 mM ammonium acetate in H 2 O + 0.05% (v/v) ammonium hydroxide, pH 10) and mobile phase B (Acetonitrile + 0.05% (v/v) ammonium hydroxide, pH 10)

Bibcode:2016NatSR...633222R

If your blood work shows you're seriously low on something like Vitamin D, for instance, you'll need a much higher, therapeutic dose to get your levels back into the optimal range
