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While the Mediterranean diet currently offers the strongest overall evidence base, flexible adaptation of its principles to accommodate individual needs appears to be the most practical and effective approach in clinical practice

88,89,90,91 They are also known as occluding junctions or zonulae occludes which can restrict the cross of hydrophilic molecules and macromolecules

Another reported pathway involves the conversion of GDP-D-mannose to GDP-L-gulose and subsequent formation of L-gulono-1, 4-lactone via L-gulose (Wolucka and van Montagu, 2003)