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Methamphetamine exposure bidirectionally regulates glutamate receptor expression depending on exposure duration [72, 73], nicotine enhances AMPA and NMDA receptor expression on VTA dopamine neurons [19, 74], and alcohol disrupts glutamate clearance by downregulating GLT-1/xCT and glutamine synthetase [75, 76]
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High quality evidence has failed to demonstrate a relationship between the MSG symptom complex and actual MSG consumption
