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Description
Gut 57, 747754 (2008)

Decitabine, an analog of 5-azacytidine, is also a potent DNMT1 inhibitor with a more favorable safety profile but decitabine is rapidly deaminated and inactivated by cytosine deaminase, if taken orally

This means it has to pass unchanged through the entire digestive tract, into the bloodstream and finally be deposited into the cells

Affiliation: Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA Email: [email protected] ORCID: Affiliation: Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA ORCID: Explor Dig Dis

Scavenger receptor A (SRA) is a cell surface glycoprotein mostly expressed in macrophages which is known to participate in multiple macrophage metabolic processes, including adhesion, phagocytosis, and host defense [110]
