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Gut 57, 747754 (2008)

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Decitabine, an analog of 5-azacytidine, is also a potent DNMT1 inhibitor with a more favorable safety profile but decitabine is rapidly deaminated and inactivated by cytosine deaminase, if taken orally

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This means it has to pass unchanged through the entire digestive tract, into the bloodstream and finally be deposited into the cells

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Affiliation: Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA Email: [email protected] ORCID: Affiliation: Department of Pharmacology, Toxicology & Therapeutics, University of Kansas Medical Center, Kansas City, KS 66160, USA ORCID: Explor Dig Dis

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Scavenger receptor A (SRA) is a cell surface glycoprotein mostly expressed in macrophages which is known to participate in multiple macrophage metabolic processes, including adhesion, phagocytosis, and host defense [110]

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