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Description
This hyperthyroid state dramatically accelerates thyroid metabolism - and with it, the generation of reactive oxygen species

Long-term supplementation should be monitored by a physician
Two clinical studies, i.e., VitDmet (NCT01479933) [101,102,103,104] and VitDbol (NCT02063334) [105,106], revealed a significant inter-individual variation in the average serum concentration of 25(OH)D and a personalised responsiveness to vitamin D 3 supplementation, allowing to distinguish three different groups, i.e., high, mid and low responders
[DOI] [PMC free article] [PubMed] [Google Scholar] 178.Regina A., Jodoin J., Khoueir P., Rolland Y., Berthelet F., Moumdjian R., Fenart L., Cecchelli R., Demeule M., Beliveau R

The study used a single high dose and did not evaluate symptoms, disease outcomes or long-term use
