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Description
This induction is significantly attenuated in Nrf2-deficient keratinocytes, indicating that 4-HNEs effects are mediated, at least in part, through the Nrf2 pathway [45]
However, constitutive activation of these signaling pathways leads to the uncontrolled proliferation of cancer cells and causes impairment in the programmed cell death, which represents the major causative factors for the development and progression of cancer [340]
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A Branson 450 sonifier set to 40 W was used to lyse the cells (8 min on ice)
