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An exploratory analysis of SURPASS-4, demonstrated that tirzepatide may have renoprotective actions compared to insulin glargine and these benefits were more pronounced in people with impaired kidney function, supporting the design of future clinical trials with tirzepatide in people with pre-existing kidney disease

However, the currently used DNMT inhibitors have limitations (an inconsistent demethylation response and high toxicity level during prolonged use), which can be potentially overcome by using combined anti-cancer therapies

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Ayoub G., Luo Y

Goel, N

Additionally, PGC-1 is known to play a regulatory role in autophagy